For normal internet users, caching is a good feature, but for web developer, it could be a problem, so here is the way to fix your Google Chrome without clearing entire cache

First solution

just add '?' in the domain

let say you are having problem with
then change it to be
and if Chrome cached already
then add another/unique query parameters, e.g.

this trick can be used for also

Second solution

open Chrome dev tools first, and click Network section
then visit the broken URL
locate network report of domain you are visiting
right click, and choose 'clear browser cache'
now reload the page